<small id="f2xv5"></small>

  •
    • <cite id="f2xv5"></cite>

        



        
  
        
  	
        
    	
        德思特生物專注于中藥（植物藥）物質基礎研究以及天然化合物、中藥化學對照品實物生產供應
        
        
    
        
  
        
  
  
        
	
        
    
    

        天然藥物活性單體及中藥對照品專業生產供應商

        
    
        聯系方式
        028-85003950
        
    
        
   
        
   
   
        
   	  
    
        

        



        
	
        
		
	
        

        




        
	
        
   	  
    


        
        
        
        	
        
        		
                
                
                
                
        
                	
        聯系方式
        
                	
        
                    	
        服務熱線：
        028-8500-3950
        公司傳真：028-85589956
        公司郵箱：sales@tcmlmt.com
        公司網址：m.chuaihan.com
        公司地址：四川省成都市溫江區?？坡肺鞫?28號5棟

                            
        
                
        
                
        	
        
            
        
            
        		
        
                	  
        
                        
        發表文獻展示
        
                        當前位置:首頁關于德思特 > 發表文獻展示 > 
                      
        
                      
        
                   		  
        
                   		  		
        International journal of analytical chemistry-13 Feb 2019 杠柳毒苷
        
                   		  		
        時間：2020-09-03   瀏覽次數：  分享到：
        
                   		  			
        
                   		  		
        
                   		  		
        
                   		  			An LC-MS/MS Method for Simultaneous Determination of the Toxic and Active Components of Cortex Periplocae in Rat Plasma and Application to a Pharmacokinetic Study
        
期刊名：International journal of analytical chemistry
        
文獻編號：DOI 10.1155/2019/1639619
        
文獻地址：https://www.hindawi.com/journals/ijac/2019/1639619/
        
發表日期：13 Feb 2019
        

        
Abstract
        
A sensitive and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determine the toxic and other active components including isovanillin, scopoletin, periplocin, periplogenin, and periplocymarin after oral administration of cortex periplocae extract to rats. Plasma samples were prepared by protein precipitation with methanol. All compounds were separated on a  column with gradient elution using acetonitrile and formic acid aqueous solution (0.1%, v/v) as the mobile phase at a flow rate of 0.3 mL/min. The detection of all compounds was accomplished by multiple-reaction monitoring (MRM) in the positive electrospray ionization mode. The LC-MS/MS method exhibited good linearity for five analytes. The lower limit of quantification (LLOQ) was 0.48 ng/mL for scopoletin, periplogenin, and periplocymarin; 2.4 ng/mL for isovanillin and periplocin. The extraction recoveries of all compounds were more than 90% and the RSDs were below 10%. It was found that the absorption of scopoletin and periplocin was rapid in vivo after oral administration of cortex periplocae extract. Furthermore, periplocymarin possessed abundant plasma exposure. The results demonstrated that the validated method was efficiently applied for the pharmacokinetic studies of isovanillin, scopoletin, periplocin, periplogenin, and periplocymarin after oral administration of cortex periplocae extract.
        

        
Periplocin (purity: 99.18%), periplocymarin (purity: 99.93%), periplogenin (purity: 99.81%), and scopoletin (purity ≥98%) were supplied from Chengdu Desite Biological Technology Co., Ltd. (Chengdu, China).
        
                   		  		
        
                   		  		
                   		  
        
                      	  
                      
        
                
        
                
                
        
                	
        
                        
        熱門新聞
        
                    
        
                    
        
                        					                                                  
        
                            
                            
        
                                
        Afrormosine CAS:550-79-8 中藥對照品標準品
        
                                
        產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...
        
                                查看更多
                            
        
                        
        
                        
          
                                                   
        
                                                                    
        
                    
                    
                
        
                
        	
        
        
        
        
    
        

        










        
	
        
	
        
        
        
        
    
        

        


        
	
        
		
    
        
    
        
		
        
		 
        德思特
        
		 
        
		 	版權所有：成都德思特生物技術有限公司 Copyright © 2016   蜀ICP備16023840號-2
        
公司地址：四川省成都市溫江區海科路西段128號5棟
        
公司電話：028-85003950
        

        
		 
        
		 
        掃一掃關注德思特
           掃碼關注公眾號
         
        
		
        		
	
        	

        
 
     
     
     
     





四虎国产永久免费久久_狠狠躁夜夜躁人人爽天天30人_成人动漫在线免费观看_久久婷婷激情综合色综合俺也去

        <small id="f2xv5"></small>
      2. 

        

        4. <cite id="f2xv5"></cite>